{"id":671,"date":"2015-05-11T19:14:07","date_gmt":"2015-05-11T19:14:07","guid":{"rendered":"http:\/\/biocyb0.cs.ucla.edu\/wp\/?page_id=671"},"modified":"2016-12-16T00:38:35","modified_gmt":"2016-12-16T00:38:35","slug":"thyrosim-apps-for-education-and-research-on-human-thyroid-hormone-regulation-dynamics","status":"publish","type":"page","link":"http:\/\/biocyb0.cs.ucla.edu\/wp\/?page_id=671","title":{"rendered":"THYROSIM Apps for Education and Research on Human\u00a0Thyroid Hormone Regulation Dynamics"},"content":{"rendered":"\t<div class=\"vc_row wpb_row vc_row-fluid\"  >\n\t<div class=\"vc_col-sm-12 wpb_column vc_column_container \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h3 style=\"text-align: center;\">THYROSIM Apps for Education and Research on Human Thyroid Hormone Regulation Dynamics<\/h3>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element  vc_custom_1431378734795\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<ul>\n<li><strong>Date:<\/strong> April 30, 2015<\/li>\n<li><strong>People:<\/strong> Simon Han (hanfresco[at]gmail.com], Marisa Eisenberg (marisae[at]umich.edu), Rotem ben Schacher, Lu Chen<\/li>\n<li><strong>Primary Citations: <\/strong>M Eisenberg , et al. <em>Thyroid<\/em>,16: 1-14 2006 <a href=\"http:\/\/www.liebertonline.com\/toc\/thy\/16\/12\">http:\/\/www.liebertonline.com\/toc\/thy\/16\/12<\/a><\/li>\n<li>THYROSIM paper: <em>Thyroid<\/em> (2016)\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26895744\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26895744<\/a><\/li>\n<li><strong><a href=\"http:\/\/biocyb1.cs.ucla.edu\/thyrosim\/\">Website<\/a><\/strong><\/li>\n<\/ul>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>We developed THYROSIM to facilitate education and research activities in endocrinology and metabolism (<strong><em>not<\/em><\/strong> self-medication!). Behind the scenes, the app runs as a well-validated and mechanistically-based model of human thyroid hormone regulation dynamics.<\/p>\n<p>The simple and intuitive user interface facilitates performance of simulated \u201cwhat-if\u201d experiments. User-selectable \u201cexperimental\u201d test-input dosages (oral hormone doses, IV-pulses, IV-infusions) are represented by animated graphical icons integrated with a cartoon of the hypothalamic-pituitary-thyroid axis (shown below). Simulations of familiar hormone (T<sub>3<\/sub>, T<sub>4<\/sub> and TSH) temporal dynamic responses to these exogenous stimuli are reported graphically along with normal ranges on the same single-page; and multiple sets of simulated experimental results are superimposable, to facilitate comparative analyses. Importantly, it is freely accessible to researchers, teachers and clinicians, from virtually anywhere, on modern hand-held devices as well as computers. It accurately reproduces a wide range of published clinical study data reporting hormonal kinetic responses to large and small oral hormone challenges. Simulation examples of treated and untreated hypothyroidism, partial-thyroidectomies and malabsorption illustrate typical usage, by optionally changing thyroid gland secretion and\/or gut absorption rates \u2013 expressed as percentages of normal \u2013 adding oral hormone dosing, all directly on the interface, and visualizing the kinetic responses to these challenges.<\/p>\n<p><strong>THYROSIM app Interface below: Example shown is a simulated hypothyroid patient\u00a0with 50% hormone secretion, with 50 \u03bcg T4 oral dose\u00a0treatment daily from day 5 for a month<\/strong><\/p>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_single_image wpb_content_element vc_align_center\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t\t<div class=\"vc_single_image-wrapper   vc_box_border_grey\"><img loading=\"lazy\" decoding=\"async\" width=\"1226\" height=\"1000\" src=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/04\/thy.png\" class=\"vc_single_image-img attachment-full\" alt=\"\" srcset=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/04\/thy.png 1226w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/04\/thy-300x245.png 300w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/04\/thy-1024x835.png 1024w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/04\/thy-940x767.png 940w\" sizes=\"(max-width: 1226px) 100vw, 1226px\" \/><\/div>\n\t\t<\/div> \n\t<\/div> \n\t\t<\/div> \n\t<\/div> \n<\/div><div class=\"vc_row-full-width\"><\/div>\n","protected":false},"excerpt":{"rendered":"THYROSIM Apps for Education and Research on Human Thyroid Hormone Regulation Dynamics Date: April 30, 2015 People: Simon Han (hanfresco[at]gmail.com], Marisa Eisenberg (marisae[at]umich.edu), Rotem ben Schacher, Lu Chen Primary Citations: M Eisenberg , et al. Thyroid,16: 1-14 2006 http:\/\/www.liebertonline.com\/toc\/thy\/16\/12 THYROSIM paper: Thyroid (2016)\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26895744 Website We developed THYROSIM to facilitate education and research activities in endocrinology","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"template-full.php","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/671"}],"collection":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=671"}],"version-history":[{"count":9,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/671\/revisions"}],"predecessor-version":[{"id":952,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/671\/revisions\/952"}],"wp:attachment":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}