{"id":695,"date":"2015-05-11T22:44:36","date_gmt":"2015-05-11T22:44:36","guid":{"rendered":"http:\/\/biocyb0.cs.ucla.edu\/wp\/?page_id=695"},"modified":"2016-12-16T01:33:23","modified_gmt":"2016-12-16T01:33:23","slug":"tumor-supressor-p53-signaling-modeling","status":"publish","type":"page","link":"http:\/\/biocyb0.cs.ucla.edu\/wp\/?page_id=695","title":{"rendered":"Tumor-supressor p53 signaling modeling"},"content":{"rendered":"\t<div class=\"vc_row wpb_row vc_row-fluid\"  >\n\t<div class=\"vc_col-sm-12 wpb_column vc_column_container \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h3 style=\"text-align: center;\">Tumor-supressor p53 signaling modeling<\/h3>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element  vc_custom_1431384260867\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<ul>\n<li><strong>Date:<\/strong> December 15, 2016<\/li>\n<li><strong><a href=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/?portfolio=tumor-supressor-p53-signaling-modeling\">Website<\/a><\/strong><\/li>\n<\/ul>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>The p53 signaling system is one of the most important and studied control systems in cellular biology and its detailed structure is still very much in discovery mode. It\u2019s known to be dysfunctional in most forms of cancer and this has been a major factor motivating numerous modeling efforts \u2013 generating a variety of different candidate structures as alternative mechanistic hypotheses \u2013 all directed toward better understanding of this system. Together, this variety of paradigms exemplify bottom-up modeling and remodeling well, for discovering what\u2019s included, excluded and how components postulated to be included are interconnected. We\u2019ve been working on discovering these major signaling pathways, based on data-driven modeling from real data collected in our collaborator Geofrey Wahl\u2019s laboratory at the Salk Institute. This is all developed in Chapters 15 and 17 of\u00a0 <em>Dynamic Systems Biology Modeling and Simulation<\/em> (Author: Joseph DiStefano III), Academic Press\/Elsevier, New York, Hardcover &amp; Electronic Editions, 2015.\u00a0 The book is available at the URL above.<\/p>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_single_image wpb_content_element vc_align_center\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t\t<div class=\"vc_single_image-wrapper   vc_box_border_grey\"><img loading=\"lazy\" decoding=\"async\" width=\"692\" height=\"423\" src=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/t53.png\" class=\"vc_single_image-img attachment-full\" alt=\"\" srcset=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/t53.png 692w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/t53-300x183.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/div>\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p><strong>p53 regulation with MdmX included with the core regulator (Mdm2 with p53). Constitutive production and degradations ae excluded. Two signaling feedback loops are present: the (outer) negative one between p53 and Mdm2; and the (inner) positive one between MdmX and Mdm2.<\/strong><\/p>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_single_image wpb_content_element vc_align_center\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t\t<div class=\"vc_single_image-wrapper   vc_box_border_grey\"><img loading=\"lazy\" decoding=\"async\" width=\"732\" height=\"528\" src=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/p53.png\" class=\"vc_single_image-img attachment-full\" alt=\"\" srcset=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/p53.png 732w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/p53-300x216.png 300w\" sizes=\"(max-width: 732px) 100vw, 732px\" \/><\/div>\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p><strong>Simulated p53 signaling responses of our quantified model to a 420 minute pulse of kinase phosphorylation of p53. This model, quantified from real data, oscillates without the need for repeated input pulsing or time delays in the feedback.<\/strong><\/p>\n\n\t\t<\/div> \n\t<\/div> \n\t\t<\/div> \n\t<\/div> \n<\/div><div class=\"vc_row-full-width\"><\/div>\n","protected":false},"excerpt":{"rendered":"Tumor-supressor p53 signaling modeling Date: December 15, 2016 Website The p53 signaling system is one of the most important and studied control systems in cellular biology and its detailed structure is still very much in discovery mode. It\u2019s known to be dysfunctional in most forms of cancer and this has been a major factor motivating","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"template-full.php","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/695"}],"collection":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=695"}],"version-history":[{"count":4,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/695\/revisions"}],"predecessor-version":[{"id":959,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/695\/revisions\/959"}],"wp:attachment":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}