{"id":700,"date":"2015-05-11T22:49:26","date_gmt":"2015-05-11T22:49:26","guid":{"rendered":"http:\/\/biocyb0.cs.ucla.edu\/wp\/?page_id=700"},"modified":"2015-05-11T22:49:26","modified_gmt":"2015-05-11T22:49:26","slug":"manganism-pbpk-modeling","status":"publish","type":"page","link":"http:\/\/biocyb0.cs.ucla.edu\/wp\/?page_id=700","title":{"rendered":"Manganism PBPK Modeling"},"content":{"rendered":"\t<div class=\"vc_row wpb_row vc_row-fluid\"  >\n\t<div class=\"vc_col-sm-12 wpb_column vc_column_container \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h3 style=\"text-align: center;\">A Hybrid PBTK Model for Manganese Distribution Dynamics in the Rat<\/h3>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element  vc_custom_1431384481463\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<ul>\n<li><strong>Date:<\/strong> March 29, 2015<\/li>\n<li><strong>Citation:<\/strong> Douglas et al. <u>J. Toxicol Environ Chem<\/u> 92: 279-299 (2010)<\/li>\n<\/ul>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>The two routes inhaled Mn can get to the striatum are: direct transneuronal transport, via the olfactory system, and indirect transfer to brain across the blood-brain barrier \u2013 via lungs-to-blood (original hypothesis). Olfactory transport of Mn means that Mn is transported transneuronally into brain, without passing into blood or other fluid first.<\/p>\n<p>Prior to this modeling study, it was not clear whether one or the other pathway dominated. The main modeling goal was to assess the relative contributions of each of these pathways quantitatively, using the rat as an experimental animal model of this process. The quantified model provided <u>a rejection of the original hypothesis<\/u> projected for this model. Instead of being one-sided, the relative contributions of olfactory (~52%) and pulmonary (~48%) pathways were estimated to be about equal.<\/p>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_single_image wpb_content_element vc_align_center\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t\t<div class=\"vc_single_image-wrapper   vc_box_border_grey\"><img loading=\"lazy\" decoding=\"async\" width=\"837\" height=\"587\" src=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/mang.png\" class=\"vc_single_image-img attachment-full\" alt=\"\" srcset=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/mang.png 837w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/mang-300x210.png 300w\" sizes=\"(max-width: 837px) 100vw, 837px\" \/><\/div>\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p><strong>Modern PBPK version equivalent of the Rat multicompartmental Mn distribution model<\/strong><\/p>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_single_image wpb_content_element vc_align_center\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t\t<div class=\"vc_single_image-wrapper   vc_box_border_grey\"><img loading=\"lazy\" decoding=\"async\" width=\"476\" height=\"485\" src=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/manganese.png\" class=\"vc_single_image-img attachment-full\" alt=\"\" srcset=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/manganese.png 476w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/manganese-294x300.png 294w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2015\/05\/manganese-49x49.png 49w\" sizes=\"(max-width: 476px) 100vw, 476px\" \/><\/div>\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p><strong>Whole body <em>pbtk<\/em> model structure with whole-body Mn distribution (<em>% of total<\/em>) and Mn compartment interchange rates as<em> mass fluxes<\/em> (<em>\u03bcg Mn\/day<\/em>) shown on arrows. Figure adapted from <\/strong><strong>(Douglas 2010 )<\/strong><\/p>\n\n\t\t<\/div> \n\t<\/div> \n\t\t<\/div> \n\t<\/div> \n<\/div><div class=\"vc_row-full-width\"><\/div>\n","protected":false},"excerpt":{"rendered":"A Hybrid PBTK Model for Manganese Distribution Dynamics in the Rat Date: March 29, 2015 Citation: Douglas et al. J. Toxicol Environ Chem 92: 279-299 (2010) The two routes inhaled Mn can get to the striatum are: direct transneuronal transport, via the olfactory system, and indirect transfer to brain across the blood-brain barrier \u2013 via","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"template-full.php","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/700"}],"collection":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=700"}],"version-history":[{"count":1,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/700\/revisions"}],"predecessor-version":[{"id":703,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/700\/revisions\/703"}],"wp:attachment":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}