{"id":966,"date":"2016-12-16T04:27:04","date_gmt":"2016-12-16T04:27:04","guid":{"rendered":"http:\/\/biocyb0.cs.ucla.edu\/wp\/?page_id=966"},"modified":"2020-10-31T00:09:35","modified_gmt":"2020-10-31T00:09:35","slug":"alternative-model-distinguishability-algorithms-the-software-app-disting","status":"publish","type":"page","link":"http:\/\/biocyb0.cs.ucla.edu\/wp\/?page_id=966","title":{"rendered":"Alternative Models"},"content":{"rendered":"<div class=\"vc_row wpb_row vc_row-fluid\"  ><\/div><div class=\"vc_row-full-width\"><\/div>\n\t<div class=\"vc_col-sm-12 wpb_column vc_column_container \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t<\/div> \n\t<\/div> \n\n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h3 style=\"text-align: center;\">Alternative Model distinguishability algorithms &amp; the software app DISTING<\/h3>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element  vc_custom_1431383457784\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<ul>\n<li><strong>Date:<\/strong> January 3, 2017<\/li>\n<li><strong>People:<\/strong> Natalie R. Davidson, Keith R. Godfrey, Faisal Alquaddoomi, David Nola and Joseph DiStefano III<\/li>\n<li><strong>Primary Citations:<\/strong> Davidson et al.\u00a0 <em>Computer Programs in Biomedicine. In press.<\/em><\/li>\n<li><strong>Website: <\/strong><span style=\"color: #0000ff;\">http:\/\/biocyb1.cs.ucla.edu\/DISTING\/<\/span><\/li>\n<\/ul>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p> The model structural indistinguishability problem is often unfamiliar or ignored by modelers, which can lead to incorrect models and false predictions.\u00a0 Algebraically, the problem is computationally complex, involving structured symbolic (non-numerical) analysis of typically large matrices. Until now, no software tools have been made available to address this problem. Our complex algorithmic solution for finding all\u00a0 structurally identifiable\u00a0alternative linear compartmental models that are input-output equivalent to a given structure is implemented in a new internet app DISTING online at this website.<\/p>\n<p>The figure below illustrates DISTING output results for a particular 4-compartment model. \u00a0 All models shown are input-output equivalent, meaning all would give identical outputs for the same inputs.\u00a0 <\/p>\n\n\t\t<\/div> \n\t<\/div> \n\t<div class=\"wpb_text_column wpb_content_element \">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t<\/div> \n\t<\/div>\n<h3 style=\"text-align: center;\"><strong>The DISTING Web App<\/strong><\/h3>\n<div id=\"attachment_997\" style=\"width: 322px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2017\/01\/4-comp-distings.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-997\" class=\" wp-image-997\" src=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2017\/01\/4-comp-distings-300x182.jpg\" alt=\"\" width=\"312\" height=\"189\" srcset=\"http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2017\/01\/4-comp-distings-300x182.jpg 300w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2017\/01\/4-comp-distings-768x465.jpg 768w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2017\/01\/4-comp-distings-1024x620.jpg 1024w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2017\/01\/4-comp-distings-940x569.jpg 940w, http:\/\/biocyb0.cs.ucla.edu\/wp\/wp-content\/uploads\/2017\/01\/4-comp-distings.jpg 1152w\" sizes=\"(max-width: 312px) 100vw, 312px\" \/><\/a><p id=\"caption-attachment-997\" class=\"wp-caption-text\">DISTING results for 4-compartment model.\u00a0 All models\u00a0 are input-output equivalent<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The DISTING Web App<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/966"}],"collection":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=966"}],"version-history":[{"count":23,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/966\/revisions"}],"predecessor-version":[{"id":1040,"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=\/wp\/v2\/pages\/966\/revisions\/1040"}],"wp:attachment":[{"href":"http:\/\/biocyb0.cs.ucla.edu\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}