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Home >> FcRn and Apoptosis Dynamics >> FcgR

Fc common g chain (component of activating FcRs) knock-out mice exhibit decreased susceptibility to mAb / FcRg meditated anti-tumor action

FcgRIIB (inhibitory FcR) knock-out mice exhibit increased susceptibility to mAb / FcRg meditated anti-tumor action

In vitro and in vivo properties of the D255A mutant antibody
contains mutations in the FcR binding portion of the mAb

For the above topics, please refer to the following reference.

Clynes et al. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets, Nature Medicine (2000) 6, 443-446.

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