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Home >> FcRn and Apoptosis Dynamics >> Evidence for a second, caspase-independent pathway

Caspase inhibition does not completely block CD20 mediated apoptosis

Overexpression of Bcl-2 does not inhibit CD20 mediated apoptosis

Overexpression of Bcl-2 prevents cytochrome c release and dissipation of mitochondrial transmembrane potential (Δψ_m), but does not completely inhibit CD20-mediated apoptosis

For the above topics, please refer to the following reference.

Van der Kolk et al. CD20-induced B cell death can bypass mitochondria and caspase activation, Leukemia (2002) 16, 1735-1744.

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