VISION-BIOMODBASE - Biocybernetics Lab, UCLA

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VISION-BIOMODBASE
Home >> PBPK >> Predict F(ab')2 Biodistribution

Predicted curve for anti-CEA F(ab’)2 fragment & biodistribution data:
Blood, Tumor, Lungs, Kidneys, Liver, Spleen, GI Tract, Bone, Carcass

Model fitting by: Ferl GZ, Wu AM, Distefano JJ, 3rd. A Predictive Model of Therapeutic Monoclonal Antibody Dynamics and Regulation by the Neonatal Fc Receptor (FcRn). Ann Biomed Eng 2005;33:1640-52.

Data from: Williams et al. Numerical Selection of Optimal Tumor Imaging Agents with Application to Engineered Antibodies. Cancer Biotherapy & Radiopharmaceuticals. 2001; 16: 25-35.