TEXTBOOKS

Joseph DiStefano III, Dynamic Systems Biology Modeling and Simulation, Academic Press/Elsevier, New York, Hardcover & Electronic Editions, 886 pages, January 24, 2015.
http://store.elsevier.com/Dynamic-Systems-Biology-Modeling-and-Simulation/Joseph-DiStefano-III/isbn-9780124104112/ http://www.amazon.com/Dynamic-Systems-Biology-Modeling-Simulation/dp/0124104118

Joseph DiStefano III, AR Stubberud & IJ Williams, Feedback and Control Systems, Second Edition: Continuous (Analog) and Discrete (Digital), McGraw-Hill, New York, April 1990. Interactive version 1994. Updated version 2013. Translated Editions in Spanish, McGraw-Hill (Bogota) 1992, Russian, etc.

http://www.amazon.com/Schaum%252019s-Outline-Feedback-Control-Systems/dp/0071829482/ref=sr_1_1?s=books&ie=UTF8&qid=1430788973&sr=1-1&keywords=distefano+feedback+and+control

Joseph DiStefano III, AR Stubberud & IJ Williams, Feedback and Control Systems, McGraw-Hill, New York, First Edition, May 1967. Translated Editions in Spanish, McGraw-Hill de Mexico, 1972; Portuguese, McGraw-Hill do Brasil, Ltda, Sao Paulo-Rio de Janeiro, 1972; Italian, Etas Libri S.p.A., Milano, 1974; Hebrew, 1974; French, Ediscience/McGraw-Hill S.A., Paris, Systems Asservis 1, 1974, Systems Asservis 2, 1975; German, McGraw-Hill Book Co., GmbH, Dusseldorf, 1976; Japanese, McGraw-Hill Book Co., Japan, 1983; Hebrew, etc.

CHAPTERS IN BOOKS

L. Stark and Joseph DiStefano III, “An Improved Sampled Data Model of the Eye Movement Control System,” Neurological Control Systems, L. Stark, ed., Plenum Press, New York, 1969, p. 290.

Joseph DiStefano III, “The Thyroid Hormone Feedback Control System,” in Applications of Engineering Principles in Physiology, J. H. U. Brown & D. S. Gann, eds., Academic Press, 1:261-289, 1973.

Joseph DiStefano III and D. A. Fisher, “Peripheral Distribution and Metabolism of the Thyroid Hormones: a Primarily Quantitative Assessment,” in International Encyclopedia of Pharmacology and Therapeutics, Section 101, The Thyroid: Physiology and Treatmet of Disease J. M. Hershman & G. A. Bray, eds., Pergamon Press, pp. 47-82, 1979.

P. Mak & Joseph DiStefano III, “Optimal Control Policies for the Prescription of Clinical Drugs: Dynamics of Hormone Replacement for Endocrine Deficiency Disorders,” in Control and Dynamic Systems: Advances in Theory and Application, C. T. Leondes, ed., Academic Press, pp. 2-41, 1979.

Joseph DiStefano III, “Some Theoretical and Practical Considerations in Modeling and Experiment Design for Quantifying Physiological and Pharmacokinetic Systems,” in Computers in Endocrinology, D. Rodbard & G. Forti, eds., Raven Press, New York, Vol. 14, pp. 259-275, 1984.

Joseph DiStefano III, “Optimal Experiment Design in Plasma Protein Metabolism Studies: Sequential Optimal Sampling Schedules for Quantifying Kinetics,” in Pathophysiology of Plasma Protein Metabolism, G. Mariani, ed., McMillan, London, pp.15-34, 1984.

Joseph DiStefano III, “Modeling Approaches and Models of the Distribution and Disposal of Thyroid Hormones,” in Thyroid Hormone Metabolism, G. Hennemann, ed., Marcel Dekker, New York, pp. 39-76, 1985.

K.R. Godfrey and Joseph DiStefano III, “Identifiability of Model Parameters,” Chapter 1, in Identifiability of Parameteric Models, (E. Walter, ed.), Pergamon Press, pp. 1-20, 1987.

Joseph DiStefano III, “Hormone Kinetic Analysis,” Chapter 160, in Endocrinology Second Edition, L. J. DeGroot, ed., Grune & Stratton, Inc., Florida, pp. 2726-2740, 1989.

Joseph DiStefano III, “Biomodel Formulation and Identification Using Optimal and Other Effective Experiment Designs”, Chapter 1 in: Modeling and Control in Biomedical Systems, C. Cobelli and L. Mariani, Eds., Pergamon Press, pp. 1-12, 1989.

Joseph DiStefano III, “Kinetic Modeling Methods in Theory and Practice”, Chapter 5, in Thyroid Hormone Metabolism-Regulation and Clinical Implications, Blackwell Scientific Publications, Inc., pp. 65-89, 1991.

EDITORIALS

Joseph DiStefano III, “Modeling Methodology Forum: a New Department,” editorial, American Journal of Physiology, 9:R257, 1981.

Joseph DiStefano III, “Noncompartmental vs. Compartmental Analysis: Some Bases for Choice,” American Journal of Physiology,243: R1-R6, 1982.

Joseph DiStefano III, “Mones Berman — a Special Tribute,” American Journal of Physiology, 245:R617, 1983.

Joseph DiStefano III, “Modeling Methodology Forum,” American Journal of Physiology, 248:E153, 1985.

S. M. Yamashiro, C-S. Poon, Joseph DiStefano III, “Modeling Pioneer: Fred S. Grodins (1915-1989)”, Journal of Applied Physiology (JAP): Modeling Methodology Forum, No. 6, 70:2763, 1991.

Joseph DiStefano III, “The Review Process for Modeling Papers: A Revisionist’s Experience with the Conventional Model”, Amerian Journal of Physiology, 30:E485-486, 1994.

RESEARCH PAPERS

Joseph DiStefano III, “Pizza alla DiStefano,” (a family recipe) Sunset Magazine, 130:184, Lane Magazine Co., Menlo Park, CA., March 1963.

Joseph DiStefano III, “Design for a Digitally-Rebalanced Closed-Loop Velocity Meter Providing a Discrete Output,” IEEE Transactions on Aerospace, AS-2:1059-1064, 1964.

Joseph DiStefano III, “The Choice of State Variables for the Determination of the Stability of Nonlinear Systems Utilizing the Second Method of Liapunov,” IEEE Transactions on Automatic Control, AC- 9:279:280, 1964.

Joseph DiStefano III, E.B. Stear & G. P. Moore, “A Model of the Thyroid Hormone Regulator and a Proposal for Its Experimental Validation,” In Proceedings of the 19th Annual Conf. on Engineering in Medicine and Biology, 8:3, 1966.

Joseph DiStefano III, and E. B. Stear, “Neuroendocrine Control of Thyroid Secretion in Living Systems: a Feedback Control System Model,” Bulletin, Math. Biophysics, 30:3-26, 1968.

Joseph DiStefano III, and E. B. Stear, “On Identification of Hypothalamo-Hypophysial Control and Feedback Relationships with the Thyroid Gland,” Journal of Theoretical Biology, 19:29-50, 1968.

Joseph DiStefano III, “Endocrine Regulation: Models and Experimental Design for System Identification,” Proceedings, Seminar on Large Scale Systems in the Mathematical Biosciences, Dubrovnik, Yugoslavia, 1968.

Joseph DiStefano III, “A Model of the Regulator of Circulating Thyroxin Unbound and Bound to Plasma Proteins and Its Response to Pregnancy, Drugs, Long Acting Thyroid Stimulator and Temperature Stress,” Math. Biosci. 4:137-152, 1969.

Joseph DiStefano III, and E. B. Stear, “Modeling and Control Aspects of Thyroid Function,” Proceedings, Conference on Hormonal Control Systems in Health and Disease, Supplement 1, Math. Biosci., American Elsevier Publishing Co., New York, 1969.

Joseph DiStefano III, “Hypothalamic and Rate Feedback in the Thyroid Hormone Regulation System: a Hypothesis,” Bulletin, Math. Biophysics., 31:233-246, 1969.

J.J. DiStefano III, “A Model of the Normal Thyroid Hormone Glandular Secretion Mechanism,” Journal of Theoretical Biology, 22:412-417, 1969.

Joseph DiStefano III, “Are There Extrathyroidal Sources of Thyroid Hormones?” Journal of Physiol. Chemistry and Physics, 1:164,170, 1969.

Joseph DiStefano III, G. Scuncio & I. Baschieri, “Oscillations in the Rate of Disappearance of Labeled Triiodothyronine from Human Plasma and the Minimum Sampling Rate for their Observation,” Experientia, 26:312- 313, 1970.

Joseph DiStefano III, “Thyroid Hormone Regulation: Models and Simulations,” Proceedings, 3rd Hawaii Int’l. Conf. on Systems Sciences, Part 1, pp. 223-226, Western Periodicals Co., 1970.

Joseph DiStefano III and R. F. Chang, “Computer Simulation of the Kinetics of Binding, Distribution and Metabolism of Thyroxine and Triiodothyronine in Man,” In Proceedings, Further Advances in Thyroid Research, 6th Int’l. Thyroid Conf., Vienna, 1970, K. Fellinger and R. Hofer, eds., Verlag der Wiener Medizinischen Akademie, Vienna, 1971, pp. 351-361.

Joseph DiStefano III and R. F. Chang, “Computer Simulation of Thyroid Hormone Binding, Distribution and Disposal Dynamics in Man,” American Journal of Physiology, 221:1529-1544, 1971.

J.H. Dussault, C. J. Hobel, Joseph DiStefano III, A. Erenberg & D. A. Fisher, “Triiodothyronine Turnover in Maternal and Fetal Sheep,” Endocrinology, 90:1301-1308, 1972.

J. DiStefano, III, “Precision Microbicannulation Device for Neuroendocrine or Neurophysiologic Applications,” Journal of Applied Physiology, 33:159-163, 1972.

G.E. Abraham, E. M. Reifman, J. E. Buster, Joseph DiStefano III, & J. R. Marshall, “Production of Specific Antibodies Against Diethylstilbestrol,” Analytical Letters, 5:479-486, 1972.

K.C. Wilson, M. Jang, P. Mak & Joseph DiStefano III, “Identification of the Dynamics of Thyroid Hormone Binding Distribution and Disposal,” Proceedings, 3rd IFAC Symposium on Identification and System Parameter Estimation, North Holland Publishing Co., Amsterdam, 1973, pp. 203-208.

Joseph DiStefano III, A. R. Durando, M. Jang, D. Jenkins, D. J. Johnson, P. Mak, T. Marshall, B. Mons, A. Warsavsky & D. A. Fisher, “Estimates and Estimation Errors of Hormone Secretion, Transport and Disposal Rates in the Maternal-Fetal System,”Endocrinology, 93:324-342, 1973.

M.L. Ownby and Joseph DiStefano III, “Parameter Estimation for Nonlinearly Observed Dynamic Systems: a Modified Quasilinearization Approach,” Proceedings, 6th Annual Southeastern Symposium on System Theory, 1974.

A. Kojima, J. M. Hershman, M. Azukizawa and Joseph DiStefano III, “Quantification of the Pituitary-Thyroid Axis in Pregnant Rats,”Endocrinology, 96:599-605, 1974.

M. Mayekawa, Joseph DiStefano III, & R. Swerdloff, “A Dynamic System Model of Testosterone Transport and Metabolism in Normal Man,” Annals of Biomedical Engineering, 2:307-320, 1974.

Joseph DiStefano III, “Use of Systems and Control Theories in Endocrinology and Metabolism,” in “Measurements, Models and Noise in Endocrine and Metabolic Systems: a Symposium Summary,” Kroc Foundation Conference Report 1, pp. 7-9, 1974.

Joseph DiStefano III, K. Wilson, M. Jang & P. H. Mak, “Identification of the Dynamics of Thyroid Hormone Metabolism,” Automatica, 11:149-159, March 1975.

Joseph DiStefano III, “In Numero Studies in Endocrinology and Metabolism: toward Computer-Aided Experimental Design,” Proceedings, 6th Summer Computer Simulation Conference, 2:935-938, July 1975.

Joseph DiStefano III, “Tracer Experiment Design for Unique Identification of Nonlinear Physiological Systems,” American Journal of Physiology, 230:476-485, 1976.

Joseph DiStefano III, and D. A. Fisher, “Peripheral Distribution and Metabolism of the Thyroid Hormones: a Primarily Quantitative Assessment,” Pharmacology and Therapeutics, 2:539-570, 1976.

Joseph DiStefano III, “Concepts, Properties, Measurement and Computation of Clearance Rates of Hormones and Other Substances in Biological Systems,” Annals of Biomedical Engineering, 4:302-319, 1976.

K. Wilson, D. A. Fisher, J. Sack & Joseph DiStefano III, “System Analysis and Estimation of Key Parameters of Thyroid Hormone Metabolism in Sheep,” Annals of Biomedical Engineering, 5:70-84, 1977.

Joseph DiStefano III, “On the Relationships Between Structural Identifiability and the Controllability, Observability Properties,” IEEE Transactions on Automatic Control, AC-22:652, 1977.

Joseph DiStefano III, and F. Mori, “Parameter Identifiability and Experiment Design: Thyroid Hormone Metabolism Parameters,”American Journal of Physiology, 233:R134-R144, 1977.

R.E. Weitzman, D. A. Fisher, Joseph DiStefano III, & C. M. Bennett, “Episodic Secretion of Arginine Vasopressin,” American Journal of Physiology, 233:E32-E36, 1977.

H. Mak and Joseph DiStefano III, “Optimal Control Policies for the Prescription of Thyroid Hormones,”Math. Biosciences, 42:159-186, 1978.

P. Hagander, K-G. Tranberg, J. Thorell & Joseph DiStefano III, “Models for the Insulin Response to Intravenous Glucose Loads,”Math. Biosciences, 42:15-29, 1978.

Joseph DiStefano III, “Optimal Design of Physiological Experiments,” Proc., Joint Automatic Control Conf., Philadelphia, PA., , 4:43-52, 1978.

Joseph DiStefano III, reply to “Comments on the Relationships between Structural Identifiability and Controllability, Observability Properties,” by C. Cobelli, A. Lepschy & G. Romanin-Jacur, IEEE Transactions on Automatic Control, 23:5, 1978.

Joseph DiStefano III, reply to “Comments on Necessary Conditions for Identifiability of Linear Systems,” by J. A. Jacquez, IEEE Transactions on Automatic Control, 23:5, 1978.

J.R. Sowers, A. E. Pekary, J. M. Hershman, M. Kanter & Joseph DiStefano III, “Metabolism of Exogenous Human Chorionic Gonadotrophin in Men,” Journal of Endocrinology, 80:83-89, 1979.

H.V. Roohk, M. Azukizawa, Joseph DiStefano III, T. Ogihara & J. M. Hershman, “Pituitary-Thyroid Hormone Periodicities in Serially-Sampled Plasma of Unanesthetized Rats,” Endocrinology, 104:851-856, 1979.

F. Mori and Joseph DiStefano III, “Optimal Nonuniform Sampling Interval and Test Input Design for Identification of Physiological Systems from Very Limited Data,” IEEE Transactions on Automatic Control, 104:893-899, 1979.

Joseph DiStefano III, and P. H. Mak, “On Model and Data Requirements for Determining the Bioavailability of Oral Therapeutic Agents: Application to Gut Absorption of Thyroid Hormones,” American Journal of Physiology, 236:R137-R141, 1979.

J.R. Allsop, R. R. Wolfe, Joseph DiStefano III, & J. F. Burke, “The Reliability of Rates of Glucose Appearance in Vivo Calculated from Single Tracer Injections,” Canadian Journal of Physiology and Pharmacology, 57:1267-1274, 1979.

Joseph DiStefano III, “Matching the Model and the Experiment to the Goals: Data Limitations, Complexity and Optimal Experiment Design for Dynamic Systems with Biochemical Signals,” Journal of Cybernetics and Information Science, 2:6-20, 1979.

Joseph DiStefano III, “Comments on Optimal Screening, Recall and Treatment of Congenital Hypothyroidism in Newborn Infants,” InProceedings of the Int’l. Conf. on Neonatal Thyroid Screening, Quebec, Canada, September 20-23, 1979.

Joseph DiStefano III, “Design and Optimization of Tracer Experiments in Physiology and Medicine,” Federation Proceedings, 39:84-90, 1980.

C. Cobelli and Joseph DiStefano III, “Parameter and Structural Identifiability Concepts and Ambiguities: a Critical Review and Analysis,” American Journal of Physiology239:R7-R24, 1980.

Joseph DiStefano III, & C. Cobelli, “On Parameter and Structural Identifiability: Nonunique Observability/Reconstructability for Identifiable Systems, Other Ambiguities and New Definitions,” IEEE Transactions on Automatic Control, AC-25:830-833, 1980.

J.J. DiStefano and C. Cobelli, authors’ reply to Lecourtier and Walter, IEEE Transactions on Automatic Control, AC-26:801-802, June 1981.

K. Okamura, A. Taurog, and Joseph DiStefano III, “Elevated Serum Levels of T3 Without Metabolic Effect in Nutritionally Deficient Rats, Attributable to Reduced Cellular Uptake of T3,”Endocrinology, 109:673- 675, 1981.

Joseph DiStefano III, “Optimized Blood Sampling Protocols and Sequential Design of Kinetic Experiments,” American Journal of Physiology, 9:R259- R265, 1981.

Joseph DiStefano III, T. K. Malone & M. Jang, “Comprehensive Kinetics of Thyroxine (T4) Distribution and Metabolism in Blood and Tissue Pools of the Rat from Only 6 Blood Samples: Dominance of Large, Slowly Exchanging Tissue Pools,” Endocrinology, 111:108-117, 1982.

Joseph DiStefano III, M. Jang, T. K. Malone & M. Broutman, “Comprehensive Kinetics of Triiodothyronine (T3) Production, Distribution and Metabolism in Blood and Tissue Pools of the Rat Using Optimized Blood Sampling Protocols,” Endocrinology, 110:198-213, 1982.

Joseph DiStefano III, “Experiences with Sequential Optimal Sampling Schedule Designs for Pharmacokinetics and Physiologic Experiments,” Proceedings, 10th IMACS World Congress on Systems Simulation and Scientific Computation, Volume 2, pp. 203-205, 1982.

C.R. Markussen and Joseph DiStefano III, “Evaluation of Four Methods for Computing Parameter Sensitivities in Dynamic System Models,” Math. Biosciences, 61:135-148, 1982.

Joseph DiStefano III, “Noncompartmental vs. Compartmental Analysis: Some Bases for Choice,” American Journal of Physiology, 243: R1-R6, 1982.

Joseph DiStefano III, “Algorithms, Software and Sequential Optimal Sampling Schedule Designs for Pharmacokinetic and Physiologic Experiments,” Mathematics & Computers in Simulation, Vol. 24, 531-534, 1982.

Joseph DiStefano III, “Comprehensive Dynamics of Distribution and Metabolism of Thyroid Hormones in Blood and Tissue Pools Using Sequentially Optimized Experiment Designs and A Priori Inequality Analysis,” In Proceedings of the 6th IFAC (International Federation of Automatic Control) Symposium on Identification and System Parameter Estimation, Pergamon Press, New York, pp. 1027-1032, 1983.

C. Cobelli, Joseph DiStefano III, L. Okolicsaniji & A. Ruggeri, “Minimal Sampling Schedules for Identification of Dynamic Models of Metabolic Systems of Clinical Interest: Case Studies for Two Liver Function Tests,” Math. Biosciences, 63:173-186, 1983.

Joseph DiStefano III, “Complete Parameter Bounds and Quasiidentifiability of Some Unidentifiable Linear Systems,” Math. Biosciences. 65:51-68, 1983.

Joseph DiStefano III, “Models of the Control of Distribution and Metabolism of Thyroid Hormone in Several Species: Comparative Aspects,” In Proceedings of the 9th World Congress, Intenational Federation of Automatic Control (IFAC), Budapest, Hungary, 6:103-108, 1984.

Joseph DiStefano III, “Some Theoretical and Practical Considerations in Modeling and Experiment Design for Quantifying Physiological and Pharmacokinetic Systems,” in International Symposium on Computers in Endocrinology, Porto Cervo, Italy, Raven Press, pp.259-275, 1984.

Joseph DiStefano III, “Workshop: Identifiability and Statistical Properties of Models and Optimization of Experiment Design,” in International Symposium on Computers in Endocrinology, Porto Cervo, Italy, Raven Press, 1984.

Joseph DiStefano III, and E. Landaw, “Multiexponential, Multicompartmental and Noncompartmental Modeling: Physiological Data Analysis and Statistical Considerations, Part I: Methodological and Physiological Interpretations,” American Journal of Physiology, 246:R651-R664, 1984.

E. Landaw and Joseph DiStefano III, “Multiexponential, Multicompartmental and Noncompartmental Modeling: Physiological Data Analysis and Statistical Considerations, Part II, Data Analysis and Statistical Considerations,” American Journal of Physiology, 246:R665- R677, 1984.

J.L. Specker, Joseph DiStefano III, R. S. Nishioka & H. A. Bern, “Development-Associated Changes in Thyroxine Kinetics in Juvenile Salmon,” Endocrinology, 115:399-406, 1984.

E.M. Landaw, B. C-M. Chen & Joseph DiStefano III, “An Algorithm for the Identifiable Parameter Combinations of the General Mamillary Compartmental Model,” Math. Biosciences, 72:199-212, 1984.

Joseph DiStefano III, reply to Claudio Cobelli & Gianna Toffolo re: “Identifiability from Parameter Bounds — Structural & Numerical Aspects,” Math. Biosciences, 71:245-246, 1984.

Joseph DiStefano III, M. Jang & M. Kaplan, “Optimized Kinetics of Reverse-Triiodothyronine (rT3) Distribution and Metabolism in the Rat: Dominance of Large, Slowly Exchanging Tissue Pools for Iodothyronines,” Endocrinology, 116:446-456, 1985.

M. Jang and Joseph DiStefano III, “Some Quantitative Changes in Iodothyronine Distribution and Metabolism in Mild Obesity and Aging,” Endocrinology, 116:457-468, 1985.

Cobelli, A. Ruggeri, Joseph DiStefano III, & E. M. Landaw, “Optimal Design of Multioutput Sampling Schedules — Software & Applications to Endocrine Metabolic & Pharmacokinetic Models,” IEEE Transactions on Biomedical Engineering, BME-32:249-256, 1985.

B. C-M. Chen, E. M. Landaw & Joseph DiStefano III, “Algorithms for the Identifiable Parameter Combinations and Parameter Bounds of Unidentifiable Catenary Compartmental Models,” Math. Biosciences, 76:59-68, 1985.

K.R. Godfrey and Joseph DiStefano III, “Identifiability of Model Parameters,” In Proceedings of the 7th IFAC/IFORS Symposium of Identification & System Parameter Estimation, 1:89-114, 1985.

J. Hershman, K. Nademanee, M. Sugawara, A. E. Pekary, R. Ross, B. Singh & Joseph DiStefano III, “Thyroxine and Triiodothyronine Kinetics in Cardiac Patients Taking Amiodarone,”Acta Endocrinologica, 111:193-199, 1986.

J. Fagarasan & Joseph DiStefano III, “Hidden Pools, Hidden Modes and Visible Repeated Eigenvalues in Compartmental Models,”Mathematical Biosciences, 82:87-113, 1986.

J. Fagarasan & Joseph DiStefano III, “On the Visibility of Leading Eigenvalues in Compartmental Models,” Mathematical Biosciences, 86:97- 110, 1987.

Joseph DiStefano III & Viveca Sapin, “Fecal and Urinary Excretion of Six Iodothyronines in the Rat,” Endocrinology, 121:1742, 1987.

Joseph DiStefano III, “Excretion, Metabolism and Enterohepatic Circulation Pathways and Their Role in Overall Thyroid Hormone Regulation in the Rat,” The American Zoologist, 28: 373-388, 1988.

Joseph DiStefano III, B. C. Chen & E. M. Landaw, “Pool Size and Mass Flux Bounds and Quasiidentifiability Conditions for Catenary Models,” Mathematical Biosciences, 88:1-14, 1988.

B.L. Chang, Joseph DiStefano III, K. Roth, E. Gonzales, D. Caswell, “CANDI: A Knowledge-Based System for Nursing Diagnosis,”Computers in Nursing, 6:13-22, 1988.

R. Lindell, Joseph DiStefano III & E. Landaw, “Statistical Variability of Parameter Bounds for n-pool Unidentifiable Mammillary and Catenary Compartmental Models,” Mathematical Biosciences, 91:175-199, 1988.

Joseph DiStefano III, D. Feng, “Comparative Aspects of the Distribution, Metabolism and Excretion of 6 Iodothyronines in the Rat”,Endocrinology, 123:2514-2525, 1988.

Joseph DiStefano III, M. Sternlicht and D. Harris, “Rat Enterohepatic Circulation and Intestinal Distribution of Enternally-Infused Thyroid Hormones”, Endocrinology, 123:2526-2539, 1988.

Joseph DiStefano III , “Biomodel Formulation and Identification Using Optimal and Other Effective Experiment Designs,” InProceedings of the 1st IFAC Symposium on Modelling and Control in Biomedical Systems, Venice, Italy, pp. 1-12, April 1988.

F. Fagarasan & Joseph DiStefano III, “Hidden Oscillations in Generalized Mammillary Compartmental Models,” Mathematical Biosciences, 93:79-95, 1989.

K. Roth, Joseph DiStefano III, B.L. Chang, “CANDI: Development of the Automated Nursing Assessment Tool”, Computers In Nursing, 7:222-227, 1989.

S. Vajda, Joseph DiStefano III, K. Godfrey & J. Fagarasan, “Parameter Space Boundaries for Unidentifiable Compartmental Models,”Mathematical Biosciences, 97:27-60, 1989.

R.L. Stephens, Jr., A. E. Pekary, Joseph DiStefano III, E. Landaw and Y. Tache, “Intracisternal Injection of TRH Precursor, TRH-Glycine, Stimulates Gastric Acid Secretion in Rats”, Regulatory Peptides, 25:51- 60, 1989.

A.E. Pekary, R. S. Stephens, M. Simard, X-P. Pang, V. Smith, Joseph DiStefano III, J. M. Hershman, “Release of Thyrotropin and Prolactin by a Thyrotropin-Releasing Hormone (TRH) Precursor, TRH-Gly: Conversion to TRH is Sufficient for In Vivo Effects”,Neuroendocrinology, 52:618-625, 1990.

D. Feng, Joseph DiStefano III, “Cut Set Analysis of Compartmental Models With Applications to Experiment Design”, American Journal of Physiology: Endocrinology & Metabolism, 261:E269-E284, 1991.

Joseph DiStefano III, T. T. Nguyen, Y-M. Yen, O. Bres, “Biliary Fluxes, Lymphatic Effluxes and Relative Uptake Dynamics of 3,5,3′-Triiodothyronine (T3) and Thyroxine (T4) from Blood to Rat Intestines, Liver and Kidneys In Vivo”, In: Progress in Thyroid Research (A. Gordon, J. Gross and G. Hennemann, eds), Rotterdam, pp. 809-811, 1991.

Marino, Joseph DiStefano III, E. M. Landaw, “DIMSUM: An Expert System for Multiexponential Model Discrimination“, American Journal of Physiology: Endocrinology & Metabolism, 262:E546-556, 1992.

D. Feng, Joseph DiStefano III, “Decomposition-Based Qualitative Experiment Design Algorithms for Compartmental Models”,Mathematical Biosciences, 110:27-43, June 1992.

Joseph DiStefano III, T. T. Nguyen, Y-M. Yen, “Sites and Patterns of Absorption of 3,5,3-Triiodothyronine (T3) and Thyroxine (T4) Along Rat Small and Large Intestines”, Endocrinology, 131:275-280, July 1992.

Joseph DiStefano III, W. Morris, T. T. Nguyen, A. Van Herle, W. Florsheim, “Enterohepatic Regulation and Metabolism of Triiodothyronine (T3) in Hypothyroid Rats”, Endocrinology, 132:1665-1670, 1993.

Joseph DiStefano III, T. T. Nguyen, Y-M. Yen, “Transfer of 3,5,3- Triiodothyronine (T3) and Thyroxine (T4) from Rat Blood to Small and Large Intestines, Liver and Kidneys In Vivo”, Endocrinology, 132:1735- 1744, 1993.

Joseph DiStefano III, A. de Luze, T. T. Nguyen, “Binding and Degradation of 3,5,3′-Triiodothyronine (T3) and Thyroxine (T4) by Rat Intestinal Bacteria“, Am. J. Physiology: Endocrinology & Metabolism, 264:966-972, 1993.

T.T. Nguyen, L-M. Huang, Joseph DiStefano III, H. Yamada, H.J. Cahnmann, “5′- and 5-Deiodinase Activity in Adult Rat Intestinal Contents Inhibited by Intestinal Microflora”, American J. Physiology: Endocrinology & Metabolism, 265:E521-E524, 1993.

T.T. Nguyen, Joseph DiStefano III, H. Yamada, Y-M. Yen, “Steady state organ distribution & metabolism of thyroxine (T4) & 3,4,3′- triiodothyronine (T3) in intestines, liver, kidneys, blood & residual carcass of the rat in vivo”, Endocrinology, 133:2973-2983, 1993.

K. Okimoto, Joseph DiStefano III, T. T. Kuwaye, G. M. Weber, B. Ron, T. T. Nguyen, S. K. Shimoda, E. G. Grau, “Plasma Volume in the Tilapia, Oreochromis Mossambicus, Maintained in Fresh Water”, Fish Physiol. Bioch. Journal, 12:431-438, 1994.

Y-M. Yen, H. Yamada, Joseph DiStefano III, and T.T. Nguyen. “Direct Measurement of Whole-Body Thyroid Hormone Pools Sizes and Interconversion Rates in Fasted Rats: Hormone Regulation Implications” Endocrinology, 134:1700-1709, 1994.

A.B. Kuhn de Chizelle, Joseph DiStefano III. “MAMCAT: An expert system for distinguishing between mammillary and catenary compartmental models“, Computers in Biology & Medicine, 24:189-204, 1994.

Joseph DiStefano III, P. Waechter, P. Abramowitz, H. T. Su, and T. T. Nguyen. ” Expert system-knowledge based biomodeling.” In Proceeding of the IFAC Symposium on Modeling and Control in Biomedical Systems, Galveston TX, pp. 1 – 6, March 1994.

D. Feng, Joseph DiStefano III, “An algorithm for identifiable parameters and parameter bounds for a class of cascaded mamillary models”, Mathematical Biosciences, 129:67-93, 1995.

A. Sefkow, Joseph DiStefano III, J.G. Eales, B.A. Himick, S.B. Brown. Thyroid hormone secretion and interconversion in 5-day fasted rainbow trout, Oncorhynchus Mykiss”, General & Comp. Endocrinology, 101:123-138, 1996.

J. P. Schroeder-van der Elst, D. van der Heide, E. Kaptein, T.J. Visser, and Joseph DiStefano III, “Differential effects of 5,5′- diphenylhydantoin on thyroid hormone metabolism and action in rats”, European J. of Endocrinology, 134:221-224, 1996.

H. Yamada, Joseph DiStefano III, Y-M. Yen and T.T. Nguyen, “Regulation of Whole Body Pool Sizes and Interconversion Rates of Thyroid Hormones in Hypo- and Mildly T3-Stimulated Rats”, Endocrinology,137:5624-5633, 1996.

Joseph DiStefano III, B. Ron, T.T. Nguyen, G.M. Weber, E.G. Grau, “3,5,3’-Triiodothyronine (T3) Clearance and T3-Glucuronide appearance kinetics in plasma of freshwater-reared male tilapia, Oreochromis mossambicus. Gen. Comp. Endo. 111:123-140, 1998.

T.T Nguyen, Chapa, F., Joseph DiStefano III. Direct Measurement of the Contributions of Type I (D1) and II (D2) 5’-Deiodinases to Whole-Body Steady State T3 Production from T4 in the Rat. Endocrinology, 139:4626-4633, 1998.

P. Vicini, H.T. Su, Joseph DiStefano III. “Identifiability and Interval Identifiability of Mammillary & Catenary Compartmental Models with Rate Parameter Constraints”, Math. Biosciences, 167: 145-161, 2000.

T.T Nguyen, Mol, K., Joseph DiStefano III. “Thyroid Hormone Production by Liver and Intestines of the Rat In Vivo: A Graph Theory/Experimental Solution for Local Sources in an Inhomogeneous Multisource Biosystems”Submitted to American Journal of Physiology: Endocrinology and Metabolism, April 2002. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12644447&query_hl=1&itool=pubmed_docsum

T.T Nguyen, Chapa, F., Joseph DiStefano III. Direct Measurement of the Contributions of Type I (D1) and II (D2) 5′-Deiodinases to Whole-Body Steady State T3 Production from T4 in the Rat. Endocrinology, 139:4626-4633, 1998.

L.H. Duntas, T.T. Nguyen, F.S. Keck, D.K. Nelson, J. J. DiStefano III. ” Changes in Metabolism of TRH in Euthyroid Sick Syndrome. European Journal of Endocrinology, 141:1-5, 1999

C. Harless and JJ DiStefano III. “Automated Biomodeling for the World-Wide Web” In Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, Vol II, CSREA Press, pp. 528-533, 2003.

T.T. Nguyen, Mol, K., Joseph DiStefano III. “Thyroid Hormone Production by Rat Liver and Intestine In Vivo: A Novel Graph Theoretic/Experimental Solution”. American Journal of Physiology: Endocrinology & Metabolism, 285:E171-181, 2003.

P. Charusanti, X Hu, L Chen, D Neuhauser, and J. J. DiStefano III “A math model of bcr-abl autophosphorylation, signaling through the crkl pathway, and Gleevec dynamics in chronic myeloid leukemia” Discrete and Continuous Dynamic Systems, Series B, 4:99-114,2004 http://aimsciences.org/journals/displayPapers.jsp?pubID=40&journID=2&pubString=Volume:%204,%20Number:%201,%20February%202004

D. Tee & JJ DiStefano III. “Simulation of Tumor-Induced Angiogenesis and its Response to Anti-Angiogenic Drug Treatment: Mode of Drug Delivery and Clearance Rate Dependencies”. Cancer Research and Clinical Oncology, 130:15-24, 2004 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed

S. Pallud, Kelly R, DiStefano JJ III, Parlow AF, Galton VA, StGermain D. “Metabolic Effect of Targeted Expression of Type 2 Iodothyroinine Deiodinase to Rodent Liver”. Mol Endocin Submitted(In Revision).

K. Bulis and JJ DiStefano III. W3MCSim: An Interactive, Intuitive and Pedagogically Useful Monte Carlo Simulator. Computer Methods and Programs in Biomedicine, 77:71-79, 2005. http://dx.doi.org/10.1016/j.cmpb.2004.08.001

C. Harless and JJ DiStefano III. Automated Expert Multiexponential Biomodeling over the Internet. Computer Methods and Programs in Biomedicine.79:169-178, August 2005 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15950310&query_hl=3&itool=pubmed_docsum

GZ Ferl, A. Wu and JJ DiStefano III. A Predictive Model of Therapeutic Monoclonal Antibody Dynamics and Regulation by the Neonatal Fc Receptor (FcRn). In Press, Annals of Biomedical Engineering, November 2005 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16341929&query_hl=2&itool=pubmed_docsum

S. Russell and JJ DiStefano III. W3MAMCAT: A Worldwide Web Based Expert System For Mammillary & Catenary Compartmental Modeling & Distinguishability. Computer Methods and Programs in Biomedicine, 2005  http://dx.doi.org/10.1016/j.cmpb.2006.03.007

Javier RM and JJ DiStefano III. Modeling the Dynamics of Biocontrol Systems Mechanistically. Proceedings of the 5th IFAC MATHMOD Conference, Vienna, Feb 2006.

S. Russell and JJ DiStefano III. W3MAMCAT: A Worldwide Web Based Expert System For Mammillary & Catenary Compartmental Modeling & Distinguishability. Computer Methods and Programs in Biomedicine, 83:34-42, July 2006. http://dx.doi.org/10.1016/j.cmpb.2006.03.007

S Hori, I Kurland and JJ DiStefano III. “Role of Endosomal Trafficking Dynamics on the Regulation of Hepatic Insulin Receptor Activity: Models for Fao Cells. Annals of Biomedical Engineering. 34(5):879-92, 2006. http://www.springerlink.com/content/u6234212174jr515/

GZ Ferl, V Kenanova, AM Wu and JJ DiStefano III. “A two-tiered physiologically-based model for dually labeled single chain Fv- Fc antibody fragments. Molecular Cancer Therapeutics. 5(6):1550-1558, 2006. http://mct.aacrjournals.org/cgi/content/full/5/6/1550

M Eisenberg, M Samuels and JJ DiStefano III, L-T4 “Bioequivalence and Hormone Replacement Studies via Feedback Control Simulations”. Thyroid, 16(12): 1-14, Dec 2006 http://www.liebertonline.com/toc/thy/16/12

M Eisenberg, M Samuels* and JJ DiStefano III. Extensions, validation & clinical applications of a feedback control system simulator of the hypothalmo-pituitary-thyroid axis. Thyroid. 1071-1085, 2008. http://www.liebertonline.com/doi/abs/10.1089/thy.2007.0388

RM Javier and JJ DiStefano III. “Dynamical Biocontrol Systems: Insights Through Mechanistic Modeling”. Mathematical and Computer Modelling of Dynamical Systems. 15:1-16, 2009 http://dx.doi.org/10.1080/13873950802379340

N. Meshkat, M. Eisenberg and JJ DiStefano III “An algorithm for finding globally identifiable parameter combinations of nonlinear ODE models using Gröbner Bases”. Mathematical Biosciences. 222 (2009) 61–7 http://www.ncbi.nlm.nih.gov/pubmed/19735669

M. Eisenberg and JJ DiStefano III. “TSH-Based Protocol, Tablet Instability, and Absorption Effects on L-T4 Bioequivalence”. Thyroid. 18: 103-110, 2009
http://www.liebertonline.com/doi/abs/10.1089/thy.2008.0148

M. Eisenberg, F. Santini, A. Marsili, A. Pinchera, and JJ DiStefano III. “TSH Regulation Dynamics in Central and Extreme Primary Hypothyroidism”. Thyroid. 20: 1215-1229, 2010
www.ncbi.nlm.nih.gov/pubmed/21062194

PK. Douglas, MS. Cohen and JJ DiStefano III. “ Chronic Exposure to Mn Inhalation may have lasting effects: A Physiologically Based Toxicokinetic Model in Rat”. Journal of Toxicology and Environmental Chemistry, 92(2):279-299 (Feb 2010).
http://www.tandfonline.com/doi/abs/10.1080/02772240902830599#.UlB97RCwVRs

Nichols, J. W., Breen, M., Denver,R. J., DiStefano III, J. J. Edwards,J. S., Hoke, R. A., Volz, D. C. and Zhang, X., Predicting Chemical Impacts On Vertebrate Endocrine Systems Environmental Toxicology and Chemistry, 30(1):39-51 (2011)
http://www.ncbi.nlm.nih.gov/pubmed/?term=Environmental+Toxicology+and+Chemistry%2C+30%281%29%3A39-51+%282011%29

Meshkat, N., Anderson, C. and DiStefano III, J. J., Finding identifiable parameter combinations in nonlinear ODE models and the rational reparameterization of their input-output equations Mathematical Biosciences, 233(1):19-31 (Sep 2011)
http://www.ncbi.nlm.nih.gov/pubmed/21763702

R Ben-Shachar, M Eisenberg, S A Huang, J J DiStefano III Simulation of Post-Thyroidectomy Treatment Alternatives for Triiodothyronine or Thyroxine Replacement in Pediatric Thyroid Cancer Patients, Thyroid (2012)
http://www.ncbi.nlm.nih.gov/pubmed/?term=ben+schacher+distefano+Pediatric+Thyroid+Cancer+Patients%2C+Thyroid.+June+2012

JJ DiStefano III Dynamic Systems Biology Modeling and Simulation. (A new textbook). Academic Press New York December (2013)
http://store.elsevier.com/Dynamic-Systems-Biology-Modeling-and-Simulation/Joseph-DiStefano-III/isbn-9780124104112/

N Meshkat, C Anderson, J J DiStefano III Alternative to Ritt’s pseudodivision for finding the input-output equations of multi-output models. Mathematical Biosciences 239: 117–123 (2012)
http://www.ncbi.nlm.nih.gov/pubmed/?term=Mathematical+Biosciences+239%3A+117%E2%80%93123+%282012%29

N Meshkat, Christine Er-zhen Kuo, Joseph DiStefano III On Finding and Using Identifiable Parameter Combinations in Nonlinear Dynamic Systems Biology Models and COMBOS: A Novel Web Implementation. PLOS ONE 9:1-14, Oct (2014) journals.plos.org/plosone/article?id=10.1371/journal.pone.0110261

SX Han, M Eisenberg, PR Larsen, J DiStefano III THYROSIM App for Education and Research Predicts Potential Health Risks of Over-the-Counter Thyroid Supplements, Thyroid (2016) https://www.ncbi.nlm.nih.gov/pubmed/26895744